CELASTROIDS

 

A unique but small group of C4-nortriterpenes having a quinone methide moiety in the A/B rings as a common feature. Celastroids have been shown to possess potent biological activity in inflammatory, cancer and related models. Cytotoxicity is an accompanying property. Modifications which can separate these properties may lead to novel and useful therapeutic agents. Unfortunately, no research addressing this question has been described. Lack of the availability of celastrol, its analogs and derivatives, has been the primary reason for this situation.

GAIA offers celastrol and other naturally occuring quinones, as described below:

 

C0250: LAWSONE

C0270: JUGLONE

C0320:DALBERGIONE, 4-METHOXY-

C0360: DALBERGIONE, 4,4'-DIMETHOXY-

C0370: DALBERGIONE, 4-METHOXY-4'-HYDROXY-

C0400:DALBERGIONE, 3,4-DIMETHOXY-

C0630: EMODIN

C0650:PHYSCION

C1200: TANSHINONE IIA

C1250: DIHYDROTANSHINONE I

C1290:CRYPTOTANSHINONE

 

C1900:BRAZILEIN

C1920:HEMATEIN

C2300:CELASTROL

C2350:CELASTROL, DIHYDRO-

C2352:CELASTROL, DIHYDRO-, DIACETATE

 

 

 

 

 

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