GAMBOGIC ACID AND DERIVATIVES

 

Gambogic acid is the principal pigment of gamboge resin which is an exudate of several Garcinia species. Gamboge has a long history of medicinal uses in Southeast Asia, and is prized for the brilliant orange color it imparts to cloth. The definition of the complex ring system of gambogic acid and the functionality dispersed throughout its framework was a major accomplishment for chemists in the sixties. Today, this complexity also offers considerable potential in new drug discovery and other biomolecular applications, as evidenced by a recent US patent (US 6,462,041); cytotoxicity has also been described (Asano et al). Gambogic acid and its derivatives can serve as novel templates in innovative drug design; nucleophylic addition, for example, readily occurs at the beta carbon to the unsaturated ketone.

GAIA provides access to research and scale-up quantities of gambogic acid and related structures.


G1000: GAMBOGIC ACID
Guttic acid, Guttatic acid, beta-Guttilactone, beta-Guttiferin
CAS#: 2752-65-0; C38H44O8; mol wt 628.76; [a]D -698 (CHCl3)
Occurrence: Garcinia Hanburryi
Appearance: Amorphous orange solid

Availability: 100 mg, 1 gram
Purity: 98% by TLC/HPLC

WD Ollis, M Ramsay, I Sutherland, S Mongkolsuk, Tetrahedron 21:1453(1965)
J Asano et al, Phytochemistry 41: 815 (1996)

 

 

G2000: GARCINOLIC ACID
C38H46O9; mol wt 646.8.
Occurrence: derivative of gambogic acid; purported to also occur in Garcinia spp
Appearance: orange amorphous solid

Availability: 100 mg, 1 gram
Purity: 95% by TLC

 


 


 

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